Take it easy!
Listened to this nice talk by Prof. Uri Alon.
One thing that really struck me was along the following lines. If you burn yourself doing science, spend too much time on it at the expense of everything else, then the stakes are too high. a) you create a blackhole for yourself, and b) tenure (or whatever else you are looking for) becomes a matter of life and death.
If you don’t do that, then you can always go and do something different if things don’t work out. So, don’t do anything so much that you exclude everything else from your life!